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Find out if you have Obstetric Cholestasis

This test reports on an expectant mother's risk for Obstetric Cholestasis. It's quick, free, and you’ll get your confidential results instantly.

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1st, 2nd, 3rd Trimester

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Postpartum Depression Test

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Symptoms & Causes

Obstetric cholestasis, also known as intrahepatic cholestasis of pregnancy (ICP), is a liver condition that occurs during pregnancy. It affects the normal flow of bile, a digestive fluid, causing it to build up in the liver and eventually spill into the bloodstream. This condition usually presents in the third trimester and resolves after delivery.

Symptoms

  • Itching: The most common symptom is intense itching, particularly on the hands and feet, but it can occur anywhere on the body. The itching often worsens at night.
  • Dark Urine: Urine may appear darker than usual.
  • Pale Stools: Stools may become pale or clay-colored.
  • Jaundice: In some cases, a yellowing of the skin and eyes (jaundice) may occur.
  • Fatigue: Extreme tiredness is also a common symptom.
  • Nausea: Feeling nauseous and experiencing a general sense of malaise can be associated with ICP.

Causes

The exact cause of obstetric cholestasis is not fully understood, but several factors are believed to contribute to its development:

  • Genetics: A family history of obstetric cholestasis can increase the likelihood of developing the condition.
  • Hormones: Pregnancy hormones are thought to play a significant role, as they can affect the normal functioning of the liver and bile production.
  • Previous Liver Conditions: Women with a history of liver conditions may be more susceptible to ICP.
  • Ethnicity: The condition is more common in certain ethnic groups, particularly in women of Scandinavian, Chilean, and Araucanian Indian descent.
  • Multiple Pregnancies: Carrying twins or triplets can increase the risk of developing obstetric cholestasis.

Diagnosis & Treatment

Diagnosing obstetric cholestasis involves a combination of symptom assessment, physical examination, and laboratory tests. Here are the key steps involved:

  • Medical History and Symptoms: The healthcare provider will take a detailed medical history and evaluate symptoms such as itching, dark urine, pale stools, and jaundice.
  • Blood Tests: Blood tests are crucial in diagnosing ICP. These tests measure liver function and bile acid levels. Elevated bile acids in the blood are a key indicator of the condition.
  • Exclusion of Other Conditions: Other liver and gallbladder conditions with similar symptoms, such as hepatitis or gallstones, will be ruled out through additional testing.
  • Monitoring: Regular monitoring of liver function and bile acid levels is important throughout the pregnancy to assess the severity of the condition.

Treatment

Treatment for obstetric cholestasis focuses on managing symptoms and minimizing risks to both the mother and the baby. Here are the common treatment approaches:

  • Ursodeoxycholic Acid (UDCA): This medication helps reduce bile acid levels and alleviate itching. It is the most commonly prescribed treatment for ICP.
  • Topical Treatments: Moisturizing creams and antihistamine medications can provide some relief from itching, although they may not be very effective in severe cases.
  • Vitamin K Supplements: To prevent bleeding complications, vitamin K supplements may be recommended as ICP can interfere with the body's ability to absorb this vitamin.
  • Regular Monitoring: Frequent blood tests to monitor liver function and bile acid levels are essential. Fetal monitoring, including ultrasound and non-stress tests, ensures the baby's well-being.
  • Early Delivery: In some cases, early delivery may be considered to reduce the risk of complications. This decision is based on the severity of the condition and the baby's gestational age.
  • Lifestyle Modifications: Some women may find relief from symptoms by avoiding triggers such as hot showers, wearing loose clothing, and staying cool.

It is important for women with obstetric cholestasis to work closely with their healthcare providers to manage the condition and ensure the best possible outcomes for both mother and baby.

When to Seek Treatment

Obstetric cholestasis can present with a variety of symptoms, but the most common and notable sign is intense itching. If you experience any of the following symptoms during your pregnancy, it is important to seek medical advice promptly:

  • Intense Itching: Persistent and severe itching, especially on the palms of the hands and the soles of the feet, that often worsens at night.
  • Dark Urine: Noticeably darker urine, despite adequate hydration.
  • Pale Stools: Stools that appear pale or clay-colored.
  • Jaundice: Yellowing of the skin and eyes, indicating a buildup of bilirubin in the blood.
  • Fatigue and Nausea: Unusual tiredness and feelings of nausea that do not have another clear cause.

Why Timely Treatment is Crucial

Seeking treatment promptly for suspected obstetric cholestasis is essential due to the potential risks to both the mother and the baby. Early diagnosis and management can help mitigate these risks:

  • Fetal Monitoring: Ensures the baby’s well-being and allows for timely interventions if necessary.
  • Symptom Relief: Helps manage intense itching and other uncomfortable symptoms, improving the mother’s quality of life during pregnancy.
  • Reducing Complications: Minimizes the risk of complications such as preterm birth, stillbirth, and bleeding problems during delivery.

Consulting Your Healthcare Provider

If you suspect you have obstetric cholestasis, contact your healthcare provider immediately. They will likely perform a physical examination, order blood tests to check liver function and bile acid levels, and discuss a treatment plan tailored to your needs.

Remember, timely intervention is key to managing obstetric cholestasis effectively and ensuring a safe pregnancy for you and your baby.